Bio-inspired chemistry and structures

Bio-inspired chemistry is an attractive approach to design organic (nano)materials with tailored properties for novel types of coatings, biosensors, delivery systems, etc. In this frame, the Laboratory for Chemistry of Novel Materials has developed approaches of supramolecular design, theoretical modeling, (chir)optical spectroscopy, and advanced scanning probe microscopy on a series of bio-inspired and biologically-relevant structures, such as :
  • Nucleic Acids as templates for tailoring the assembly/polymerization of functional molecules
  • DNA hybridization biosensors based on ?-conjugated polyelectrolytes
  • Polymer coatings for stimuli-responsive bioadhesives
  • Fiber-forming biomolecular structures : cellulose nanowhiskers, peptide hydrogels

Bio-inspired chemistry and structures

Model of chiral complexation between a cationic polythiophene (purple) and ssDNA (gray ribbon, bases in blue).

Bio-inspired chemistry and structures

5 µm x 5 µm PeakForce Tapping topographic image of cellulose nanowhiskers.
On the Mechanism of Dynamic Polymerization viaRecycled ss-DNA Templated Assembly of Non-Natural Bases. J. Lin, M. Surin, D. Beljonne, X. Lou, J.L.J. van Dongen, A.P.H.J. Schenning. Chemical Science 3 (2012) 2372-2376.

Chirality in DNA-? Conjugated Polymer Supramolecular Structures: Insights into the Self-Assembly. J.Rubio-Magnieto, A. Thomas, S. Richeter, A. Mehdi, Ph.Dubois, R. Lazzaroni, S. Clément, M. Surin. Chemical Communications 49 (2013) 5483- 5485.

What Are the Parameters Controlling Inter-vs. Intra-Strand DNA Photodamage with Ru-TAP Oligonucleotides? S. Le Gac, M. Surin, E. Defrancq, C. Moucheron, A. Kirsch - De Mesmaeker. European Journal of Inorganic Chemistry (2013) 208–216.

Chemical Force Microscopy of Stimuli-Responsive Adhesive Copolymers. A. Beaussart, T. Chinh Ngo, S. Derclaye, R. Kalinova, R. Mincheva, Ph. Dubois, Ph. Leclère, Y.F. Dufrêne. Nanoscale, 6 (2014), 565 – 571.

Modification of the Adhesive Properties of Silicone based-Coatings by Block Copolymers. T. C. Ngo, R. Kalinova, D. Cossement, E. Hennebert, R. Mincheva, R. Snyders, P. Flammang, Ph. Dubois, R. Lazzaroni, and Ph. Leclère. Langmuir, 30 (2014), 358 – 368.